Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.
Identifieur interne : 000005 ( Main/Exploration ); précédent : 000004; suivant : 000006Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.
Auteurs : Elisa Baranski Lamback [Brésil] ; Monica Amorim De Oliveira [Brésil] ; Andrea Ferreira Haddad [Brésil] ; André Filipe Marcondes Vieira [Brésil] ; Armando Leão Ferreira Neto [Brésil] ; Taciana Da Silva Maia [Brésil] ; Juliana De Rezende Chrisman [Brésil] ; Pedro Pimenta De Mello Spineti [Brésil] ; Marco Antonio De Mattos [Brésil] ; Eduardo Costa [Brésil]Source :
- The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [ 1678-4391 ]
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Azithromycine, Hydroxychloroquine.
- Adulte, Adulte d'âge moyen, Association de médicaments, Brésil, Humains, Études rétrospectives.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Azithromycin, Hydroxychloroquine.
- geographic : Brazil.
- drug therapy : COVID-19.
- Adult, Drug Therapy, Combination, Humans, Middle Aged, Retrospective Studies, SARS-CoV-2.
Abstract
OBJECTIVES
To assess the efficacy of hydroxychloroquine in combination with azithromycin in terms of clinical and biochemical outcomes in adult patients with COVID-19 hospitalized for acute respiratory distress syndrome (ARDS), and to describe the occurrence of adverse events.
METHOD
Retrospective comparative study, based in a quaternary private hospital in Rio de Janeiro, Brazil, involving 193 adult patients hospitalized for mild and moderate COVID-19 related ARSD, analyzing treatment efficacy based on clinical and biochemical outcomes.
RESULTS
The active group comprised 101 (52.3%) patients using hydroxychloroquine associated with azithromycin and the control group 92 (47.7%) patients who did not take these medications. Median age was 59 (47-70) in the active group and 65 (47-77) in the control group (p < 0.05). Patients in the control group had greater extent of pulmonary involvement on baseline chest CT scans (p < 0.05). All other baseline variables (BMI, comorbidities, previous use of medications and biochemical assessments) were similar between groups. In the medication group, 25% (25 out of 101) were admitted to the ICU, compared to 21% (19 out of 92) in the control group (p > 0.05). No difference in mortality, duration of non-invasive oxygen use or duration of hospitalization was seen between groups. The therapeutic regimen was well tolerated, with only eight (7.9%) patients presenting gastrointestinal symptoms and eight (7.9%) patients withdrawn treatment due to QTc prolongation.
CONCLUSIONS
Patients treated with hydroxychloroquine combined with azithromycin and the control group had similar clinical outcomes. This therapeutic regimen was considered ineffective in hospitalized patients with mild to moderate COVID-19 related ARDS and was associated with few non-severe adverse events.
DOI: 10.1016/j.bjid.2021.101549
PubMed: 33621543
PubMed Central: PMC7894091
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.</title><author><name sortKey="Lamback, Elisa Baranski" sort="Lamback, Elisa Baranski" uniqKey="Lamback E" first="Elisa Baranski" last="Lamback">Elisa Baranski Lamback</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, Brazil. Electronic address: elisalamback@gmail.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Oliveira, Monica Amorim De" sort="Oliveira, Monica Amorim De" uniqKey="Oliveira M" first="Monica Amorim De" last="Oliveira">Monica Amorim De Oliveira</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Haddad, Andrea Ferreira" sort="Haddad, Andrea Ferreira" uniqKey="Haddad A" first="Andrea Ferreira" last="Haddad">Andrea Ferreira Haddad</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Vieira, Andre Filipe Marcondes" sort="Vieira, Andre Filipe Marcondes" uniqKey="Vieira A" first="André Filipe Marcondes" last="Vieira">André Filipe Marcondes Vieira</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil; Universidade Federal Fluminense, Niterói, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil; Universidade Federal Fluminense, Niterói, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Neto, Armando Leao Ferreira" sort="Neto, Armando Leao Ferreira" uniqKey="Neto A" first="Armando Leão Ferreira" last="Neto">Armando Leão Ferreira Neto</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Maia, Taciana Da Silva" sort="Maia, Taciana Da Silva" uniqKey="Maia T" first="Taciana Da Silva" last="Maia">Taciana Da Silva Maia</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Chrisman, Juliana De Rezende" sort="Chrisman, Juliana De Rezende" uniqKey="Chrisman J" first="Juliana De Rezende" last="Chrisman">Juliana De Rezende Chrisman</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Unimed-Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Spineti, Pedro Pimenta De Mello" sort="Spineti, Pedro Pimenta De Mello" uniqKey="Spineti P" first="Pedro Pimenta De Mello" last="Spineti">Pedro Pimenta De Mello Spineti</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Mattos, Marco Antonio De" sort="Mattos, Marco Antonio De" uniqKey="Mattos M" first="Marco Antonio De" last="Mattos">Marco Antonio De Mattos</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Costa, Eduardo" sort="Costa, Eduardo" uniqKey="Costa E" first="Eduardo" last="Costa">Eduardo Costa</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Unimed-Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021 Mar-Apr</date><idno type="RBID">pubmed:33621543</idno><idno type="pmid">33621543</idno><idno type="doi">10.1016/j.bjid.2021.101549</idno><idno type="pmc">PMC7894091</idno><idno type="wicri:Area/Main/Corpus">000318</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000318</idno><idno type="wicri:Area/Main/Curation">000318</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000318</idno><idno type="wicri:Area/Main/Exploration">000318</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.</title><author><name sortKey="Lamback, Elisa Baranski" sort="Lamback, Elisa Baranski" uniqKey="Lamback E" first="Elisa Baranski" last="Lamback">Elisa Baranski Lamback</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, Brazil. Electronic address: elisalamback@gmail.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Oliveira, Monica Amorim De" sort="Oliveira, Monica Amorim De" uniqKey="Oliveira M" first="Monica Amorim De" last="Oliveira">Monica Amorim De Oliveira</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Haddad, Andrea Ferreira" sort="Haddad, Andrea Ferreira" uniqKey="Haddad A" first="Andrea Ferreira" last="Haddad">Andrea Ferreira Haddad</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Vieira, Andre Filipe Marcondes" sort="Vieira, Andre Filipe Marcondes" uniqKey="Vieira A" first="André Filipe Marcondes" last="Vieira">André Filipe Marcondes Vieira</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil; Universidade Federal Fluminense, Niterói, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil; Universidade Federal Fluminense, Niterói, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Neto, Armando Leao Ferreira" sort="Neto, Armando Leao Ferreira" uniqKey="Neto A" first="Armando Leão Ferreira" last="Neto">Armando Leão Ferreira Neto</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Maia, Taciana Da Silva" sort="Maia, Taciana Da Silva" uniqKey="Maia T" first="Taciana Da Silva" last="Maia">Taciana Da Silva Maia</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Chrisman, Juliana De Rezende" sort="Chrisman, Juliana De Rezende" uniqKey="Chrisman J" first="Juliana De Rezende" last="Chrisman">Juliana De Rezende Chrisman</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Unimed-Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Spineti, Pedro Pimenta De Mello" sort="Spineti, Pedro Pimenta De Mello" uniqKey="Spineti P" first="Pedro Pimenta De Mello" last="Spineti">Pedro Pimenta De Mello Spineti</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Mattos, Marco Antonio De" sort="Mattos, Marco Antonio De" uniqKey="Mattos M" first="Marco Antonio De" last="Mattos">Marco Antonio De Mattos</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Unimed Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Costa, Eduardo" sort="Costa, Eduardo" uniqKey="Costa E" first="Eduardo" last="Costa">Eduardo Costa</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Unimed-Rio, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author></analytic><series><title level="j">The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases</title><idno type="eISSN">1678-4391</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Azithromycin (adverse effects)</term><term>Brazil (MeSH)</term><term>COVID-19 (drug therapy)</term><term>Drug Therapy, Combination (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (adverse effects)</term><term>Middle Aged (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Association de médicaments (MeSH)</term><term>Azithromycine (effets indésirables)</term><term>Brésil (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (effets indésirables)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Middle Aged</term><term>Retrospective Studies</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Brésil</term><term>Humains</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To assess the efficacy of hydroxychloroquine in combination with azithromycin in terms of clinical and biochemical outcomes in adult patients with COVID-19 hospitalized for acute respiratory distress syndrome (ARDS), and to describe the occurrence of adverse events.</p></div><div type="abstract" xml:lang="en"><p><b>METHOD</b></p><p>Retrospective comparative study, based in a quaternary private hospital in Rio de Janeiro, Brazil, involving 193 adult patients hospitalized for mild and moderate COVID-19 related ARSD, analyzing treatment efficacy based on clinical and biochemical outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The active group comprised 101 (52.3%) patients using hydroxychloroquine associated with azithromycin and the control group 92 (47.7%) patients who did not take these medications. Median age was 59 (47-70) in the active group and 65 (47-77) in the control group (p < 0.05). Patients in the control group had greater extent of pulmonary involvement on baseline chest CT scans (p < 0.05). All other baseline variables (BMI, comorbidities, previous use of medications and biochemical assessments) were similar between groups. In the medication group, 25% (25 out of 101) were admitted to the ICU, compared to 21% (19 out of 92) in the control group (p > 0.05). No difference in mortality, duration of non-invasive oxygen use or duration of hospitalization was seen between groups. The therapeutic regimen was well tolerated, with only eight (7.9%) patients presenting gastrointestinal symptoms and eight (7.9%) patients withdrawn treatment due to QTc prolongation.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Patients treated with hydroxychloroquine combined with azithromycin and the control group had similar clinical outcomes. This therapeutic regimen was considered ineffective in hospitalized patients with mild to moderate COVID-19 related ARDS and was associated with few non-severe adverse events.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">33621543</PMID><DateCompleted><Year>2021</Year><Month>05</Month><Day>17</Day></DateCompleted><DateRevised><Year>2021</Year><Month>05</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1678-4391</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>2</Issue><PubDate><MedlineDate>2021 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases</Title><ISOAbbreviation>Braz J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.</ArticleTitle><Pagination><MedlinePgn>101549</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1413-8670(21)00012-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bjid.2021.101549</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess the efficacy of hydroxychloroquine in combination with azithromycin in terms of clinical and biochemical outcomes in adult patients with COVID-19 hospitalized for acute respiratory distress syndrome (ARDS), and to describe the occurrence of adverse events.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Retrospective comparative study, based in a quaternary private hospital in Rio de Janeiro, Brazil, involving 193 adult patients hospitalized for mild and moderate COVID-19 related ARSD, analyzing treatment efficacy based on clinical and biochemical outcomes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The active group comprised 101 (52.3%) patients using hydroxychloroquine associated with azithromycin and the control group 92 (47.7%) patients who did not take these medications. Median age was 59 (47-70) in the active group and 65 (47-77) in the control group (p < 0.05). Patients in the control group had greater extent of pulmonary involvement on baseline chest CT scans (p < 0.05). All other baseline variables (BMI, comorbidities, previous use of medications and biochemical assessments) were similar between groups. In the medication group, 25% (25 out of 101) were admitted to the ICU, compared to 21% (19 out of 92) in the control group (p > 0.05). No difference in mortality, duration of non-invasive oxygen use or duration of hospitalization was seen between groups. The therapeutic regimen was well tolerated, with only eight (7.9%) patients presenting gastrointestinal symptoms and eight (7.9%) patients withdrawn treatment due to QTc prolongation.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients treated with hydroxychloroquine combined with azithromycin and the control group had similar clinical outcomes. This therapeutic regimen was considered ineffective in hospitalized patients with mild to moderate COVID-19 related ARDS and was associated with few non-severe adverse events.</AbstractText><CopyrightInformation>Copyright © 2021 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lamback</LastName><ForeName>Elisa Baranski</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, RJ, Brazil. Electronic address: elisalamback@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliveira</LastName><ForeName>Monica Amorim de</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haddad</LastName><ForeName>Andrea Ferreira</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieira</LastName><ForeName>André Filipe Marcondes</ForeName><Initials>AFM</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil; Universidade Federal Fluminense, Niterói, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neto</LastName><ForeName>Armando Leão Ferreira</ForeName><Initials>ALF</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maia</LastName><ForeName>Taciana da Silva</ForeName><Initials>TDS</Initials><AffiliationInfo><Affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chrisman</LastName><ForeName>Juliana de Rezende</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spineti</LastName><ForeName>Pedro Pimenta de Mello</ForeName><Initials>PPM</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil; Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattos</LastName><ForeName>Marco Antonio de</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Hospital Unimed Rio, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costa</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Instituto Unimed-Rio, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>02</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Brazil</Country><MedlineTA>Braz J Infect Dis</MedlineTA><NlmUniqueID>9812937</NlmUniqueID><ISSNLinking>1413-8670</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="Y">COVID-19</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="Y">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Azithromycin</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">Severe acute respiratory syndrome coronavirus 2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>01</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>02</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>23</Day><Hour>20</Hour><Minute>8</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33621543</ArticleId><ArticleId IdType="pii">S1413-8670(21)00012-X</ArticleId><ArticleId IdType="doi">10.1016/j.bjid.2021.101549</ArticleId><ArticleId IdType="pmc">PMC7894091</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>État de Rio de Janeiro</li></region></list><tree><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Lamback, Elisa Baranski" sort="Lamback, Elisa Baranski" uniqKey="Lamback E" first="Elisa Baranski" last="Lamback">Elisa Baranski Lamback</name></region><name sortKey="Chrisman, Juliana De Rezende" sort="Chrisman, Juliana De Rezende" uniqKey="Chrisman J" first="Juliana De Rezende" last="Chrisman">Juliana De Rezende Chrisman</name><name sortKey="Costa, Eduardo" sort="Costa, Eduardo" uniqKey="Costa E" first="Eduardo" last="Costa">Eduardo Costa</name><name sortKey="Haddad, Andrea Ferreira" sort="Haddad, Andrea Ferreira" uniqKey="Haddad A" first="Andrea Ferreira" last="Haddad">Andrea Ferreira Haddad</name><name sortKey="Maia, Taciana Da Silva" sort="Maia, Taciana Da Silva" uniqKey="Maia T" first="Taciana Da Silva" last="Maia">Taciana Da Silva Maia</name><name sortKey="Mattos, Marco Antonio De" sort="Mattos, Marco Antonio De" uniqKey="Mattos M" first="Marco Antonio De" last="Mattos">Marco Antonio De Mattos</name><name sortKey="Neto, Armando Leao Ferreira" sort="Neto, Armando Leao Ferreira" uniqKey="Neto A" first="Armando Leão Ferreira" last="Neto">Armando Leão Ferreira Neto</name><name sortKey="Oliveira, Monica Amorim De" sort="Oliveira, Monica Amorim De" uniqKey="Oliveira M" first="Monica Amorim De" last="Oliveira">Monica Amorim De Oliveira</name><name sortKey="Spineti, Pedro Pimenta De Mello" sort="Spineti, Pedro Pimenta De Mello" uniqKey="Spineti P" first="Pedro Pimenta De Mello" last="Spineti">Pedro Pimenta De Mello Spineti</name><name sortKey="Vieira, Andre Filipe Marcondes" sort="Vieira, Andre Filipe Marcondes" uniqKey="Vieira A" first="André Filipe Marcondes" last="Vieira">André Filipe Marcondes Vieira</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000005 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000005 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33621543
|texte= Hydroxychloroquine with azithromycin in patients hospitalized for mild and moderate COVID-19.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33621543" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |